In addition, the pathological results related to coronavirus disease 2019 (COVID-19) are analogous to those reported previously in the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) pandemics, and biopsy samples of lung tissues depict lesions in bilateral diffuse alveolar with cellular fibromyxoid exudates. The identification of hundreds of proteins, such as DNA, biotin–streptavidin, and S-protein, as well as different kinds of bacteria and viruses is crucial to understand any type of abnormal behavior inside living cells. The detection and accurate analysis of nanoscale biomolecules is becoming an everyday requirement due to several recent findings in the field of microbiology. The proposed device can thus be used as an alternative to conventional FET-based biosensors.
The results indicate that the proposed biosensor exhibits a S Vth value of 0.68 for positively charged biomolecules at a very low drain bias of 0.2 V. Furthermore, the linearity, distortion, and noise immunity of the device are evaluated to confirm the overall performance of the biosensor at high (GHz) frequency. In addition, radiofrequency (RF) sensing parameters such as the transconductance gain and the cutoff frequency are taken into account to provide further insight into the sensitivity of the proposed device. Additionally, S Vth (the V th sensitivity) is also analyzed, considering both positively and negatively charged biomolecules.
Various sensing parameters such as the I ON/ I OFF ratio and the threshold voltage shift are evaluated as metrics to validate the proposed sensing device. We propose and investigate a biosensor based on a transparent dielectric-modulated dual-trench gate-engineered metal–oxide–semiconductor field-effect transistor (DM DT GE-MOSFET) for label-free detection of biomolecules with enhanced sensitivity and efficiency.
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